[Download] "Cefepime Monotherapy Is As Effective As Ceftriaxone Plus Amikacin in Pediatric Patients with Cancer and High-Risk Febrile Neutropenia: A Randomized Comparison (Clinical Report)" by American Journal of Infectious Diseases # Book PDF Kindle ePub Free
eBook details
- Title: Cefepime Monotherapy Is As Effective As Ceftriaxone Plus Amikacin in Pediatric Patients with Cancer and High-Risk Febrile Neutropenia: A Randomized Comparison (Clinical Report)
- Author : American Journal of Infectious Diseases
- Release Date : January 01, 2008
- Genre: Life Sciences,Books,Science & Nature,
- Pages : * pages
- Size : 233 KB
Description
Abstract: The empirical use of antibiotic therapies is widely accepted in patients with fever and neutropenia during cancer chemotherapy. The use of intravenous monotherapy with broad-spectrum antibiotics in patients with high-risk of complications is an appropriate alternative. However, few data are available in pediatric patients. We conducted a prospective, randomized, open study in patients with lymphoma or leukemia who had fever and neutropenia during chemotherapy. Patients were randomized to receive cefepime (CFP) or ceftriaxone plus amikacin (CFT+AK). A total of 57 patients with 125 episodes of fever and neutropenia were evaluated (CFP, 62 and CFT + AK, 63 episodes). The mean neutrophil count at admission was 118.6 cells [mm.sup.-3] (CFP) and 107 cells [mm.sup.-3] (CFT+AK). The mean duration of neutropenia was 9.0 days (CFP) and 8.0 days (CFT+AK). Analyzing only the first episodes of each patient, CFP treatment was successful in 65.5% of the episodes and CFT+AK were successful in 64.3%. Overall rates of success with modification were 90% (CFP) and 89% (CFT+AK). No major treatment-emergent toxicity was reported. Monotherapy with CFP seems to be as effective and safe as the combination of CFT+AK for initial empirical therapy in children and adolescents with NF. Key words: Febrile neutropenia, cefepime, high-risk, leukemia, lymphoma.
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